Health care workers at the University of Miami Miller School of Medicine verify which participants receive vaccine or placebo during a phase 3 coronavirus disease vaccine clinical trial being conducted there in September The situation has spurred debate about the ethics, let alone the feasibility, of continuing or launching blinded, placebo-controlled trials—generally considered the gold standard of medical research—of investigational COVID vaccines. Trial participants are hearing mixed messages, Wendler said. Public health leaders are urging the public to get vaccinated, but researchers are suggesting that trial participants remain blinded and forgo vaccination for at least a few more months, he said. In other words, as severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 circulated more widely, trial participants were more likely to be exposed to it. So COVID cases among those who received placebo shots accumulated rapidly, enabling trials to show a clear efficacy difference between the control and active immunization groups. But the speed with which 2 COVID vaccines received EUAs throws a wrench into ongoing and future placebo-controlled vaccine trials: Why would anyone want to remain or enroll in such studies when they could get vaccinated outside of them? But in most states, only health care workers, nursing home residents and staff, and people aged 65 years or older were eligible for vaccine by late January.
EDT MR. And thanks for amalgamation us. Walensky, Dr. Fauci, Dr. Driven by the more catching Delta variant, cases are progress to rise.
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